4 edition of Mechanisms of drug resistance in neoplastic cells found in the catalog.
|Statement||edited by Paul V. Woolley III, Kenneth D. Tew.|
|Series||Bristol-Myers cancer symposia ;, 9|
|Contributions||Woolley, Paul V., Tew, Kenneth D., Bristol-Myers Symposium on Cancer Research (9th : 1986 : Washington, D.C.)|
|LC Classifications||RC271.C5 M43 1988|
|The Physical Object|
|Pagination||xxv, 390 p. :|
|Number of Pages||390|
|LC Control Number||87012656|
Starts 01/ Council. The Mechanisms of Cancer Therapeutics-1 (MCT1) Study Section review applications addressing the mechanisms of action of anti-neoplastic agents including the effects of therapy on tumor cell growth, cell death, gene expression, and signaling networks, mechanisms of resistance to anti-neoplastic agents and therapeutic methods including resistance to . Drug resistance 1. DRUG RESISTANCEBy Muhammed rashid ak Medical college calicut 2. Unresponsiveness of a microorganism to an antimicrobial. Drug resistance is the reduction in effectiveness of a drug such as an antimicrobial or an antineoplastic in curing a disease or condition. When an organism is resistant to more than one drug, it is said to be .
stage of diagnosis, efficacy of treatment, type of cancer (doubling time), patient health overall, drug resistance development Exposure to multiple drugs with multiple mechanisms and sites of action: destroys more subpopulation of cells. overgrowth of drug-resistant variants and the rapid acquisition of drug resistance by many cancers. For the past 40 years, researchers have been tabulating the various mechanisms by which cancer cells grown in tissue culture become resistant to anticancer drugs (Figure 1). Some of these mechanisms, such as loss of a cell surface receptor orFile Size: KB.
Drug resistance, either intrinsic or acquired, remains one of the primary causes of failure for cancer chemotherapy. This chapter focuses on alterations in the carrier mediated transport systems that are responsible for intrinsic and acquired resistance. As with the antifolate drugs, a single, or a combination of different, mechanism(s) can mediate resistance to nucleoside Author: Michael P. Draper, Graham K. Jones, Christopher J. Gould, David E. Modrak. Ends 10/ Council. The Basic Mechanisms of Cancer Therapeutics [BMCT] Study Section reviews applications addressing the mechanisms of action of anti-neoplastic agents, mechanisms of resistance to anti-neoplastic agents and method to circumvent drug resistance.
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The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells.
The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase. Purchase Mechanisms of Drug Resistance in Neoplastic Cells - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. Mechanisms of drug resistance in neoplastic cells.
San Diego: Academic Press, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: Paul V Woolley; Kenneth D Tew. Buy Mechanisms of Drug Resistance in Neoplastic Cells: Bristol-Myers Cancer Symposia, Vol.
9: Read Kindle Store Reviews - Get this from a library. Mechanisms of drug resistance in neoplastic cells. [Paul V Woolley; Kenneth D Tew;] -- Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor.
Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. Mechanisms of Drug Resistance in Neoplastic Cells (Bristol-myers Cancer Symposia) by Paul V.
Woolley (Author), Kenneth D. Tew (Editor) Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell. Mechanisms of Drug Resistance in Neoplastic Cells.
Bristol–Myers Cancer Symposia, Volume 9 | Paul V. Woolley and Kenneth D. Tew (Eds.) | download |. Novel mechanisms of drug resistance in leukemia. it is reasonable to postulate that neoplastic cells may use a versatile combinatorial strategy to The Transporter Fact Book Academic Press Cited by: Mechanisms of drug resistance of neoplastic cells The multidrug resistance (MDR) of neoplastic cells represents a real obstacle in the effective treatment of neoplastic diseases [ 25 ].
MDR could be an inherent property of tissue from which neoplastic cells were developed – primary (intrinsic) MDR, or could be induced by prior treatment with Author: Lucia Messingerova, Denisa Imrichova, Martina Coculova, MarianZelina, Lucia Pavlikova, Helena Kavcov.
Tumour-EVs can mediated drug resistance through several mechanisms, including drug sequestration, delivery of specific RNA molecules and proteins, or through the well-known crosstalk between. Tsuruo T. Mechanisms of multidrug resistance and implications for therapy.
Jpn J Cancer Res. Mar; 79 (3)– Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. Increased accumulation of vincristine and adriamycin in drug-resistant P tumor cells following incubation with calcium antagonists and calmodulin by: 1. Med Princ Pract. ;14 Suppl Mechanisms of drug resistance in cancer chemotherapy.
Luqmani YA(1). Author information: (1)Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Kuwait. [email protected] The management of cancer involves procedures, which include surgery, radiotherapy and by: Transfection and overexpression of BCRP in drug-sensitive cells confers drug-resistance to the cells.
BCRP is a half-transporter, and may homodimerize or form heterodimers (with a. Drug resistance can be the result of the induction of a variety of protective mechanisms or the result of the selection of resistant clones.
In some cases, neoplastic cells may also have a high intrinsic level of resistance .Cited by: Buy (ebook) Mechanisms of Drug Resistance in Neoplastic Cells by Kenneth D. Tew, Paul V. Woolley, eBook format, from the Dymocks online bookstore.
Keywords:paclitaxel, drug resistance, reversal of drug resistance, in vivo drug resistance assays, mdr, pgp, tubulin, cytokine Abstract: It has been approximately ten years since the Food and Drug Administration (FDA) approved paclitaxel for the treatment of.
Drug resistance (DR) is the major limiting factor in the successful treatment of systemic neoplasia with cytotoxic chemotherapy. DR can be either intrinsic or acquired, and although the development and clinical implications are different, the underlying mechanisms are likely to be similar.
Most causes for DR are pharmacodynamic in nature, result from adaptations within the Cited by: 6. The emergence of diverse resistance mechanisms to targeted therapy is one of the foremost challenges in cancer today the same patient or even tumour, multiple mechanisms of drug Cited by: About this book Introduction In Cytotoxic Drug Resistance Mechanisms, leading clinical and laboratory scientists describe cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumors.
Eukaryotic Cell Genetics reviews the state of knowledge in somatic cell genetics. The book begins by discussing the development of somatic cell genetics, focusing on the estimation of mutation rates in mammalian cells, with frequent reference to the use of drug resistance as a selective character.A number of mechanisms contributing to acquired resistance to 5-FU-based therapies include alteration of the drug’s specific target, drug inactivation, influx and efflux of drugs in the cells, drug-induced damage, and evasion of by: 1.
— Researchers have discovered a mechanism of drug resistance to Venetoclax®, also known as ABT, a BCL-2 targeting drug commonly used to treat chronic lymphocytic leukemia and.